PVC comes in two basic forms: rigid … Most vinyl chloride is used to make polyvinyl chloride (PVC) plastic and vinyl products. See Also: Toxicological Abbreviations Vinyl Chloride (EHC 215, 1999) Vinyl Chloride (HSG 109, 1999) Vinyl chloride (WHO Food Additives Series 19) VINYL CHLORIDE (JECFA Evaluation) Vinyl chloride (PIM 558) Vinyl Chloride (IARC Summary & Evaluation, Supplement7, 1987) Vinyl Chloride (IARC Summary & Evaluation, Volume 7, 1974) Symptoms of Raynaud, although statistically associated with exposure, were not related to capillaroscopic modifications; its origin remains to be determined. Vinyl-chloride disease is, however, clinically very similar to scleroderma, and the observations by ourselves and others that susceptibility to scleroderma is linked, albeit weakly, to HLA markers4-6 led us to study 44 of the 53 patients with symptoms of vinyl-chloride disease originally described by Ward et al. Vinyl chloride is used to make polyvinyl chloride (PVC). It burns easily and it is not stable at high temperatures. Vinyl chloride (Figure 8.2), which is produced for industrial use as a chemical intermediate in the manufacture of other compounds, particularly polyvinyl chloride (PVC), is toxic by all routes of exposure. Dermal exposure to vinyl chloride may cause irritation, pain and burns. The most common symptoms are: Dizziness. Vinyl chloride can be found in urine and body tissues after recent exposures. Visual disturbances or confusion. Symptoms/disease. Acute (short-term) exposure to high levels of vinyl chloride in air has resulted in central nervous system effects (CNS), such as dizziness, drowsiness, and headaches in humans. Design Cross-sectional study. Vinyl chloride is used primarily to make polyvinyl chloride (PVC); PVC is used to make a variety of plastic products, including pipes, wire and cable coatings and packaging materials. Participants We screened 761 (97% men) retired workers exposed to chemical toxics. INTRODUCTION Vinyl chloride monomer (VCM) is primarily used in the manufacture of plastics and also serves as a raw material in organic synthesis. Function tests of bone marrow, liver, kidney, and nerves may be useful in determining the effects of vinyl chloride exposure. [ifediba.com] The gas can cause dizziness, drowsiness, and headache when inhaled. Ataxia. Drowsiness There are certain symptoms that are likely to appear if you have been exposed to vinyl chloride. Occupational agents Vinyl chloride Raynaud’s phenomenon, sclerodactyly, acro-osteolysis, hepatic fibrosis, angiosarcoma, plaque-like fibrotic cutaneous lesions, leuco- and thrombocytopaenia Organic solvents Skin fibrosis, irritant dermatitis, hepatitis, neurological symptoms [Note: Shipped as a liquefied compressed gas.] Vinyl chloride: A substance used in manufacturing plastics that is known to be toxic and carcinogenic (cancer-causing).Dangerous exposure to vinyl chloride occurs mainly in the workplace. Design: Cross-sectional study. TO VINYL CHLORIDE FINAL REPORT SCIENCE APPLICATIONS, INC, 1801 AVENUE OF THE STARS SUITE 1205 Los ANGELES, CALIFORNIA 90067 . Symptoms were commonly reported by first responders, most frequently headache, upper respiratory irritation, and lower respiratory irritation. Vinyl chloride is a respiratory irritant producing coughing, wheezing and breathlessness. There are a number of test methods that can be used to indirectly assess symptoms of vinyl chloride exposure. Participants: We screened 761 (97% men) retired workers exposed to chemical toxics. Vinyl chloride can be detected in the urine after recent exposures. Studies of workers in polyvinyl chloride polymerization of certain plastic and rubber factories revealed that numerous workers had been diagnosed with liver angiosarcoma. Toxic Exposure Injury Attorneys - Serving Clients Nationwide. It is metabolized to the active metabolites chloroethylene oxide and chloracetaldehyde, which is responsible for its toxicity. Vinyl Chloride 75-01-4 _____ Hazard Summary . Studies in workers who inhale vinyl chloride over many years show an increased risk of … Vinyl chloride is a colorless gas. time-related exposure response. Angiosarcoma attacks the lining of blood vessels, and can occur in any area of the body. vinyl chloride vapors: acroosteolysis, scleroderma, and Raynaud's phenomenon. Civilian Exposure is a fully tax-exempt, non-profit news and outreach organization. This test is not routinely available at most medical facilities, and its results may not accurately reflect the level or the duration of the exposure. Objectives: To assess residual long-term microcirculation abnormalities by capillaroscopy, 15 years after retiring from occupational exposure to vinyl chloride monomer (VCM). Acute exposure to vinyl chloride can cause dizziness, drowsiness, unconsciousness, and at extremely high levels can cause death. Reported New or Worsened Symptoms Overall, 58% of participants in the In-Person Survey and 66% in the Mailed Survey reported experiencing new or worsening symptoms in … No specific antidote. Chronic exposure to levels around 100-1000 ppm has been associated with a range of symptoms collectively termed ‘vinyl chloride disease’, including Raynaud’s syndrome, scleroderma and acro-osteolysis—bone resorption of the terminal phalanges of the fingers. There are a number of ways in which a person can become exposed to vinyl chloride, including through: Inhalation; Drinking contaminated water; Work - people who work with vinyl chloride are at the highest risk of vinyl chloride exposure Other effects include headache, ataxia and coma [3, 4]. Most vinyl chloride is used to make polyvinyl chloride (PVC) plastic and vinyl products. Occupational exposure to vinyl chloride was lower in workers without neurological findings. Vinyl Chloride is used mainly to make PVC products. 9.1.5 Parenteral exposure Not reported. It has a mild, sweet odor. Treatment of exposure should be directed at the control of symptoms and the clinical condition of the patient. While these were prevalent in extraordinary amounts in the groundwater and soil for decades at […] Reply. Symptoms of Vinyl Chloride Exposure. Vinyl chloride exposure has been shown to increase the risk of a rare form of liver cancer called angiosarcoma. 9.1.6 Other Not reported. Objectives To assess residual long-term microcirculation abnormalities by capillaroscopy, 15 years after retiring from occupational exposure to vinyl chloride monomer (VCM). The degree of toxicity may be influenced the duration and level of exposure to the chemical. Irritation of the respiratory tract. This report details the investigation of exposures and symptoms … Symptoms of Vinyl Chloride Exposure. Setting Allier, one of the major areas of polyvinyl chloride production in France. Health effects may occur from exposure to vinyl chloride at concentrations below the odor threshold. Vinyl chloride toxicity occurs mainly through occupational exposure during the polymerization of VCM into PVC; however, community exposures secondary to industrial spills have occurred. Stimulants such as epinephrine may induce ventricular fibrillation. 9.2.2 Inhalation Repeated exposure to vinyl chloride may induce vinyl chloride disease which is characterized by scleroderma-like changes of the fingers, Raynaud's phenomenon and acro-osteolysis. Chloroethene, Chloroethylene, Ethylene monochloride, Monochloroethene, Monochloroethylene, VC, VCM, Vinyl chloride monomer (VCM) Colorless gas or liquid (below 7°F) with a pleasant odor at high concentrations. In 2012 in New Jersey, a train derailment resulted in the puncture of a tanker car carrying liquid vinyl chloride under pressure, and a resulting airborne vinyl chloride plume drifted onto the grounds of a nearby refinery. Frequency of the arterial hypertension was the same in both groups, whereas acroparesthesias, Raynaud's syndrome, and increased gamma GTP serum activity were significantly more frequent in workers with neurological disturbances. Vapours of vinyl chloride are moderately irritating to the eyes. It can be formed when other substances such as trichloroethane, trichloroethylene, and tetrachloroethylene are broken down. Reproductive toxicity -- Vinyl Chloride: Vinyl Chloride is a suspected reproductive toxicant and exposure to it has the potential to negatively affect the human reproductive system. It is a manufactured substance that does not occur naturally. Doctors pinpointed the carcinogenicity of vinyl chloride in the late 1960s. However, test results may not accurately reflect the level or duration of the exposure, or predict future health effects. Setting: Allier, one of the major areas of polyvinyl chloride production in France. Vinyl chloride is also produced as a combustion product in tobacco smoke. Cardiotoxicity -- Vinyl Chloride: Introduction. Polyvinyl chloride (colloquial: polyvinyl, vinyl; abbreviated: PVC) is the world's third-most widely produced synthetic plastic polymer (after polyethylene and polypropylene).About 40 million tons of PVC are produced each year. ... PCE, benzene and vinyl chloride. Cardiotoxicity -- Vinyl Chloride: Exposure to Vinyl Chloride can have a toxic effect on the heart and may result in blood vessel tumors. Additionally, there are reports of cases of significant chronic exposure related to aerosol propellant usage in the 1960s and early 1970s, although VCM is no longer utilized in this manner. Inebriation. Because personal breathing zone measurements of responders' exposures to vinyl chloride were not collected, it is impossible to correlate vinyl chloride exposure levels with symptoms. Fatigue. Acute (short-term) exposure to high levels of vinyl chloride in air has resulted in central nervous system (CNS) effects, such as dizziness, drowsiness, and headaches in humans. vinyl chloride resulting in excessive exposure to workers or when workers develop symptoms of vinyl chloride exposure. Short-term exposure to moderate levels of vinyl chloride in the air can result in a headache, vertigo, loss of consciousness, and fatigue.Nervous system damage is also possible. 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